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Masteron (Drostanolone Dipropionate)

Masteron (Drostanolone Dipropionate) muscle mass

Masteron (Drostanolone Dipropionate)

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Chemical structure Drostanolone dipropionate is an anabolic, (known as dromostanolone) is an altered dihydrotestosterone.

Drostanolone dipropionate is an anabolic (known as dromostanolone) – altered dihydrotestosterone. It is distinguished by the addition of a methyl group in the 2alpha position, which affects the increase in the anabolic strength of the steroid, increasing the resistance to metabolism by the enzyme 3a-hydroxysteroid dehydrogenase in muscle tissues (2alpha, 5alpha, 17 beta) -17-Hydroxy-2-methyandrostan-3-one formula C20H32O2 … Drostanolone propionate is a modified form of drostanolone, with a propionate ester attached through a 17-beta hydroxyl group. Unlike free steroids, esterified steroids are less polar, therefore, they are not absorbed as quickly from the injection site. Once in the circulatory system, the ether is split off and free drostanolone moves through the blood. The aim of the development of esterified steroids was to increase the period of therapeutic effect after administration, to inject less frequently when compared with taking free steroids. Drostanolone propionate has a half-life of approximately two days after injection. In the medical literature, drostanolone is described as a powerful anabolic with anti-estrogenic properties. Despite this, many scientists admit that the anabolic properties of drostanol are rather moderate when compared with similar drugs. It is widely used by athletes who are on a diet, as well as those involved in high-speed and strength sports, in which its property is necessary to influence the increase in muscle mass and strength, reducing the body fat, while not having serious side qualities.

History reference

Drostanolone propionate was described back in 1959. Its development was carried out by Syntex, along with oxymethalone and methyldrostanolone, despite this, the drug appeared in pharmacies only 10 years later. An agreement was made between Lilly and Syntex on the joint application of developments. The former sold drostanolone propionate in the United States, calling it drolban, and the latter distributed the same drug in other markets. In Belgium it was called Masteron, in Great Britain and Bulgaria – Craftsman, in Spain – Metormone, in France – Permastril, in Japan – Mastisol, and in the GDR – Masteride. The US Food and Drug Administration has approved drostanolone propionate for the treatment of inoperable breast cancer in postmenopausal women. This is how it was used in the world. There is evidence in the medical literature that drostanolone propionate gave less virilization when compared with testosterone propionate. Despite this, there are records in the records that high doses (about 300 mg in 7 days) caused virilization. Drostanolone was widely used by athletes in the 70s and 80s, but in medicine it was used with some restrictions. When other methods of treating breast cancer appeared, the production of drostanolone became less, and then they stopped altogether, gradually it disappeared from the market..

pharmachologic effect

Reduces the production of luteotropic and follicle-stimulating hormones. Drostanolone dipropionate has an androgenic (when compared with testosterone propinate, it is expressed less) and anabolic (expressed more than that of testosterone propionate) action. It has an antitumor effect in patients with thymus cancer, even in the presence of metastases, and in patients with suppressed ovarian function due to radiation, androgenic drugs, or undergoing oophorectomy. The effect is more pronounced when performing bilateral oophorectomy. It has an anabolic effect, it is expressed in the stimulation of protein synthesis, a decrease in fat deposition, a delay in the human body necessary for the synthesis of protein potassium, phosphorus, sulfur, an increase in calcium fixation in bones and an increase in muscle mass. Has a stimulating effect on the production of erythropoietin when there is sufficient protein nutrition.

Drostanolone Dipropionate Steroid Profile

The activity of the substance is 2-3 days

Classification: Steroid of Anabolic / Androgenic origin

Application method: by injection

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Dosages: Men 300-500mg for 7 days; Women 25-50mg for 7 days

Acne: Yes

Water Retention: No

High blood pressure: Sometimes

Hepatotoxicity: No

Aromatase: No

Progestogenic Activity: No

DHT (Dehydrotestosterone) Conversion: No

Decreased HPTA function (production of your own testosterone): yes

Anabolic activity (25-40%); Androgenic activity (62-130%)

Masteron (Drostanolone Dipropionate) increase muscle

The detection time is 14 days (approximately, since the doping commission is constantly looking for new and improving methods for detecting prohibited substances, it also depends on the athlete using the drug, whether he uses phenobarbital and furosemide to accelerate the withdrawal of the drug)

Effects of drostanolone dipropionate

Gives good effect when used for drying purposes

Affects muscle density

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Influences the increase in strength indicators, reducing body fat, gives a good effect when used before competition

Application of drostanolone dipropionate:

Reception (for men):

The recommended dose of the drug is 300-500 mg / in 7 days, usually on the third day, or one after one. Duration of the course is 6 (8) -10 (12) weeks. Usually combined with nandrolone decanoate or boldenone undesilinate, this affects the increase in muscle mass, while not excessively retaining water. In order to gain mass, it is combined with injectable testosterone, this affects the growth of muscle mass without excess “water”, which would accumulate if taken with other drugs. Drostanolone is also used for “drying” purposes. It is combined with other non-aromatizing drugs such as stanozolol, primobolan, trenbolone or oxandrolone, and this helps to keep the muscles on a diet and cut..

Reception (for women):

Women are not advised to take the drug due to high androgenicity..

For medical purposes, drostanolone was prescribed at 100 mg x 3 r every 7 days, 2-3 months, then the result should be assessed. Signs of virilization were significant at this dosage. In order to improve the physique, the drug is taken at 25-50 mg in 7 days, for 4-6 weeks. It should also be said that due to the speed of the propionate ether, the drug must be injected every second or third day..

Side effects of drostanolone dipropionate

Drostanolone does not aromatize and has no estrogenic activity. Anti-estrogens are not needed, even sensitive people will not notice the manifestations of gynecomastia. As a rule, estrogen retains water, but in those taking this steroid, quality mass increases without excess fluid. In this regard, it is good to use the drug for drying, it is then that the main problem is water and fat retention. As a non-aromatizing derivative of dihydrotestosterone, drostanolone may exhibit some anti-estrogenic effect, while competing with other substances for binding to aromatase.

Although drostanolone is classified as an anabolic, androgenic side effects may be present. High doses of the drug can cause increased oily skin, acne, hair growth on the body and face. Anabolic steroids are likely to worsen male-pattern hair loss. Women should be reminded of the possible virilizing effects of AAS (coarsening of the voice, irregular periods, changes in skin texture, facial hair growth, and clitoral enlargement). Drostanolone does maxdrol not react with 5a-reductase and its androgenicity cannot be changed by the parallel use of finasteride or dutasteride. Despite the fact that it is a steroid with low androgenic activity, the threshold for its buy sustanon 250 androgenic side effects is much higher than that of testosterone, methandrostenolone and fluoxymesterone.

Drostanolone is a non-alkylated drug in the 17-alpha position, therefore it has no hepatotoxic properties.

AAS can have harmful effects on blood cholesterol. This may be a decrease in the level of “good” HDL, a shift in the balance towards the risk of atherosclerosis. The relative effect of AAS on lipids depends on dose, route of administration, type of steroid and level of resistance to hepatic metabolism. Drostanolone has a more pronounced negative effect on hepatic cholesterol management than testosterone and nandrolone, as it has a non-aromatizing structure, but the effect is less than that of 17-alpha alkylated drugs. AAS can negatively affect blood pressure and triglycerides, decrease vascular endothelial relaxation, provoke ventricular hypertrophy, and this potentially increases the risk of cardiovascular disease and heart attack. To reduce the stress on the cardiovascular system, it is advised to minimize the dragonpharmacy.com intake of saturated fats, cholesterol and simple carbohydrates during the course of the AAS. Recommend supplements such as fish oil, lipid stable and similar products.

All AAS, at doses required for muscle building, suppress endogenous testosterone production. If you do not take substances that stimulate the production of testosterone, it will come to its normal level within 1-4 months after the course. It should be noted that long-term hypogonadotropic hypogonadism can develop into secondary and it is likely that medical intervention will be required..

Indications for drug use drostanolone dipropionate

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Breast cancer, including metastases, in women with a preserved menstrual cycle or menopause before 5 years.

Contraindications to the drug use of drostanolone dipropionate

Should not be taken by people with the following diseases: hypersensitivity, acute diseases of the liver, kidneys, cardiovascular system (myocardial infarction, severe hypertension, hypertensive crisis), hypercalcemia, end-stage breast cancer.

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